Sadie Coles HQ is a contemporary art gallery in London which presents work by established and emerging artists. The gallery opened in the West End in 1997. The inaugural exhibition – new paintings by American artist John Currin – was presented in parallel to an exhibition by British artist Sarah Lucas, The Law, in a temporary location on St John Street. This pairing established the international dimension of the gallery's programme, which continues to this day. Sadie Coles HQ currently represents forty-eight artists from around the world.

Sadie Coles HQ has operated from a variety of spaces since its foundation, while staging off-site projects in various locations in London and abroad. In 2015, the gallery opened a new permanent space at 1 Davies Street, designed by 6a Architects, with an exhibition by Rudolf Stingel. This accompanies a larger space at 62 Kingly Street which opened in in September 2013. Exhibitions are presented at both sites throughout the year.

Sadie Coles HQ currently participates in up to seven international art fairs each year; and in recent years, the gallery has enjoyed a growing profile in Asia, participating in fairs including Art Basel Hong Kong, Westbund Shanghai and ART021 Shanghai. In 2017, Sadie Coles HQ presented an exhibition of contemporary art from China, Zhongguo 2185, featuring several artists not previously seen in the UK. In the past five years, Sadie Coles HQ has begun representing a significant number of new artists including Michele Abeles, Uri Aran, Darren Bader, Shannon Ebner, Kati Heck, Helen Marten, Borna Sammak, Ryan Sullivan, Martine Syms, and Jordan Wolfson. This is in addition the continued representation of artists including Sarah Lucas, John Currin, Elizabeth Peyton, Urs Fischer, Carl Andre, Rudolf Stingel, and the Estate of Angus Fairhurst.