From the late 50s, exhibited artists included those coming out of St Ives, Patrick Heron, Terry Frost and Roger Hilton, and a new generation of British painters and sculptors, Peter Blake and Patrick Caulfield, Elisabeth Frink, Anthony Caro and William Turnbull. The gallery would become instrumental in the promotion of post-war American art in England, showing the influential work of Milton Avery in 1962, Abstract Expressionists and the emergent Color Field painting of Morris Louis, Kenneth Noland, and Helen Frankenthaler. In the early 70s, contemporary shows became interspersed with the work of European and British masters, Pablo Picasso, Henri Matisse, Fernand Léger, Jean Dubuffet and Ben Nicholson. New European and American painters and sculptors were introduced in the 80s, including Barry Flanagan and Michael Craig-Martin, Julian Schnabel, Dan Flavin, Donald Judd and Robert Rauschenberg, and in the 90s, young British artists, Ian Davenport and Fiona Rae.

Waddington Custot represents contemporary British artists David Annesley, Peter Blake and Ian Davenport and French painter Fabienne Verdier, sculptors Jedd Novatt and Pablo Reinoso, the Estates of Allan D'Arcangelo, Patrick Caulfield, Barry Flanagan and Patrick Heron. The inventory includes works by modern British masters, Henry Moore and Ben Nicholson, and important twentieth-century European artists, Henri Matisse, Pablo Picasso, Jean Dubuffet, Josef Albers, Fausto Melotti, and Antoni Tàpies. The long-standing focus on American artists continues with representation of Robert Indiana and works by John Chamberlain, Peter Halley, Robert Rauschenberg, Haim Steinbach, Frank Stella and John Wesley.