El-Sayegh is concerned with the part-to-whole relations in philosophy and science, and how fragments of information can be re-formed to generate new meaning. Her practice is inherently fluid, involving processes of layering, erasure, and obfuscation. These processes are at play in the artist's ongoing 'Net-Grid' series, started in 2010, in which fragments of writing and images can be seen through layers of paint that have been applied using the wet-on-wet technique so that each layer absorbs into the next. On top, a hand-painted grid further obscures the layers while 'holding in' the information beneath—a literal reference to a net, and the act of catching something.

El-Sayegh's 'Net-Grid' paintings appear as cohesive compositions from afar; however, close up, elements appear sectioned off from each other by the grid. This micro-to-macro dynamic is at play across the artist's practice. Exhibitions of her artwork often include vitrines of what she calls her 'archive'—objects and images that mirror the composites of her paintings. In the artist's first institutional solo exhibition in the United Kingdom at Chisenhale Gallery, titled Cite Your Sources (12 April–9 June 2019), objects and images in vitrines included bars of Imperial Leather soap and iPhone cases, their display addressing the process of categorisation. Also on view in the exhibition were pages from the Financial Times, applied directly to the walls and floor of the gallery and overlaid with inscriptions in English and Arabic, along with maps and schematics. The pinkish hue of the paper recalled the tone of human flesh and the body's implicit entanglement in global economic, political, and social structures.

In an Ocula Conversation with Para Site deputy director Claire Shea, transcribed from a talk held in advance of the artist's solo exhibition at Lehmann Maupin in Hong Kong (Dispersal, 11 July–23 August 2019), El-Sayegh explains her approach to the show as an interest in 'this idea of an explosion, and a way to kind of start again from that.' This 'reformation of parts', as she calls it, is also at play in her ongoing 'Piece Paintings' (2010–ongoing), which are composed of disparate imagery—the body being a recurring feature—and text, including logos, which, the artist explains, 'have a magical quality that can be likened to witchcraft'.

El-Sayegh was shortlisted for the 7th edition of the Max Mara Art Prize for Women in 2017. That same year, the artist's installation Boundary Work was exhibited at Sharjah Biennial 13, having been commissioned by the Sharjah Art Foundation. The artist's works have been included in a number of group exhibitions, including Ecologies of Darkness at S A V V Y Contemporary in Berlin (2019).

Tessa Moldan | Ocula | 2019